Prospect and challenge of detecting dynamic gene copy number increases in stem cells by whole genome sequencing

ABSTRACT: Gene amplification is an evolutionarily well-conserved and highly efficient mechanism to increase the amount of specific proteins. In humans, gene amplification is a hallmark of cancer and has recently been found during stem cell differentiation. Amplifications in stem cells are restricted...

Descripción completa

Detalles Bibliográficos
Autores principales: Fischer, Ulrike, Backes, Christina, Fehlmann, Tobias, Galata, Valentina, Keller, Andreas, Meese, Eckart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647207/
https://www.ncbi.nlm.nih.gov/pubmed/31134286
http://dx.doi.org/10.1007/s00109-019-01792-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647207/
https://www.ncbi.nlm.nih.gov/pubmed/31134286
http://dx.doi.org/10.1007/s00109-019-01792-y

Ejemplares similares