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Prospect and challenge of detecting dynamic gene copy number increases in stem cells by whole genome sequencing
ABSTRACT: Gene amplification is an evolutionarily well-conserved and highly efficient mechanism to increase the amount of specific proteins. In humans, gene amplification is a hallmark of cancer and has recently been found during stem cell differentiation. Amplifications in stem cells are restricted...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647207/ https://www.ncbi.nlm.nih.gov/pubmed/31134286 http://dx.doi.org/10.1007/s00109-019-01792-y |