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Patient recruitment strategies for adaptive enrichment designs with time-to-event endpoints

BACKGROUND: Adaptive enrichment designs for clinical trials have great potential for the development of targeted therapies. They enable researchers to stop the recruitment process for a certain population in mid-course based on an interim analysis. However, adaptive enrichment designs increase the t...

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Detalles Bibliográficos
Autores principales: Uozumi, Ryuji, Yada, Shinjo, Kawaguchi, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647323/
https://www.ncbi.nlm.nih.gov/pubmed/31331277
http://dx.doi.org/10.1186/s12874-019-0800-2