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Biguanide is a modifiable pharmacophore for recruitment of endogenous Zn(2+) to inhibit cysteinyl cathepsins: review and implications
ABSTRACT: Excessive activities of cysteinyl cathepsins (CysCts) contribute to the progress of many diseases; however, therapeutic inhibition has been problematic. Zn(2+) is a natural inhibitor of proteases with CysHis dyads or CysHis(Xaa) triads. Biguanide forms bidentate metal complexes through the...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647370/ https://www.ncbi.nlm.nih.gov/pubmed/31044334 http://dx.doi.org/10.1007/s10534-019-00197-1 |