Neuronal Expression of UBQLN2(P497H) Exacerbates TDP-43 Pathology in TDP-43(G348C) Mice through Interaction with Ubiquitin

Mutations in the gene encoding ubiquilin-2 (UBQLN2) are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). UBQLN2 plays a central role in ubiquitin proteasome system (UPS) and UBQLN2 up-regulation exacerbates TDP-43 cytoplasmic aggregates. To analyze interaction between...

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Detalles Bibliográficos
Autores principales: Picher-Martel, Vincent, Renaud, Laurence, Bareil, Christine, Julien, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647471/
https://www.ncbi.nlm.nih.gov/pubmed/30377984
http://dx.doi.org/10.1007/s12035-018-1411-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647471/
https://www.ncbi.nlm.nih.gov/pubmed/30377984
http://dx.doi.org/10.1007/s12035-018-1411-3

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