Study on the Heterogeneity of T-DM1 and the Analysis of the Unconjugated Linker Structure under a Stable Conjugation Process

[Image: see text] Trastuzumab emtansine (T-DM1) is a target-specific anticancer antibody-drug conjugate (ADC). In the present study, critical quality attributes for different manufactured products, such as the drug to antibody ratio (DAR), conjugation site, and site conjugation ratio, are similar, w...

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Detalles Bibliográficos
Autores principales: Wu, Guanghao, Gao, Yanbo, Liu, Datao, Tan, Xiaoding, Hu, Lide, Qiu, Zidan, Liu, Jingyan, He, Huidan, Liu, Yanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648207/
https://www.ncbi.nlm.nih.gov/pubmed/31459971
http://dx.doi.org/10.1021/acsomega.9b00430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648207/
https://www.ncbi.nlm.nih.gov/pubmed/31459971
http://dx.doi.org/10.1021/acsomega.9b00430

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