Synthesis and Pharmacological Evaluation of [(11)C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

[Image: see text] The α(4/6)βδ-containing GABA(A) receptors are involved in a number of brain diseases. Despite the potential of a δ-selective imaging agent, no PET radioligand is currently available for in vivo imaging. Here, we report the characterization of DS2OMe (1) as a candidate radiotracer,...

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Detalles Bibliográficos
Autores principales: L’Estrade, Elina T., Hansen, Hanne D., Falk-Petersen, Christina, Haugaard, Anne, Griem-Krey, Nane, Jung, Sascha, Lüddens, Hartmut, Schirmeister, Tanja, Erlandsson, Maria, Ohlsson, Tomas, Knudsen, Gitte M., Herth, Matthias M., Wellendorph, Petrine, Frølund, Bente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648289/
https://www.ncbi.nlm.nih.gov/pubmed/31459972
http://dx.doi.org/10.1021/acsomega.9b00434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648289/
https://www.ncbi.nlm.nih.gov/pubmed/31459972
http://dx.doi.org/10.1021/acsomega.9b00434

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