Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots

[Image: see text] Compound promiscuity is often attributed to nonspecific binding or assay artifacts. On the other hand, it is well-known that many pharmaceutically relevant compounds are capable of engaging multiple targets in vivo, giving rise to polypharmacology. To explore and better understand...

Descripción completa

Detalles Bibliográficos
Autores principales: Gilberg, Erik, Gütschow, Michael, Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648413/
https://www.ncbi.nlm.nih.gov/pubmed/31459430
http://dx.doi.org/10.1021/acsomega.8b03481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648413/
https://www.ncbi.nlm.nih.gov/pubmed/31459430
http://dx.doi.org/10.1021/acsomega.8b03481

Ejemplares similares