Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

[Image: see text] We describe our work to establish structure- and fragment-based drug discovery to identify small molecules that inhibit the anti-apoptotic activity of the proteins Mcl-1 and Bcl-2. This identified hit series of compounds, some of which were subsequently optimized to clinical candid...

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Detalles Bibliográficos
Autores principales: Murray, James B., Davidson, James, Chen, Ijen, Davis, Ben, Dokurno, Pawel, Graham, Christopher J., Harris, Richard, Jordan, Allan, Matassova, Natalia, Pedder, Christopher, Ray, Stuart, Roughley, Stephen D., Smith, Julia, Walmsley, Claire, Wang, Yikang, Whitehead, Neil, Williamson, Douglas S., Casara, Patrick, Le Diguarher, Thierry, Hickman, John, Stark, Jerome, Kotschy, András, Geneste, Olivier, Hubbard, Roderick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648477/
https://www.ncbi.nlm.nih.gov/pubmed/31459977
http://dx.doi.org/10.1021/acsomega.9b00611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648477/
https://www.ncbi.nlm.nih.gov/pubmed/31459977
http://dx.doi.org/10.1021/acsomega.9b00611

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