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Targeting Translation Activity at the Ribosome Interface with UV-Active Small Molecules

[Image: see text] Puromycin is a well-known antibiotic that is used to study the mechanism of protein synthesis and to monitor ribosome activity due to its incorporation into nascent peptide chains. However, puromycin effects outside the ribosome catalytic core remain unexplored. Here, we developed...

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Detalles Bibliográficos
Autores principales: Kandala, Divya T., Del Piano, Alessia, Minati, Luca, Clamer, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648492/
https://www.ncbi.nlm.nih.gov/pubmed/31460127
http://dx.doi.org/10.1021/acsomega.9b00366