Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)

[Image: see text] A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spiroox...

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Autores principales: Kolle, Shivalinga, Barak, Dinesh S., Ghosh, Aritra, Jaiswal, Vandana, Kant, Ruchir, Batra, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648575/
https://www.ncbi.nlm.nih.gov/pubmed/31459716
http://dx.doi.org/10.1021/acsomega.9b00396
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author Kolle, Shivalinga
Barak, Dinesh S.
Ghosh, Aritra
Jaiswal, Vandana
Kant, Ruchir
Batra, Sanjay
author_facet Kolle, Shivalinga
Barak, Dinesh S.
Ghosh, Aritra
Jaiswal, Vandana
Kant, Ruchir
Batra, Sanjay
author_sort Kolle, Shivalinga
collection PubMed
description [Image: see text] A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl(3)-mediated intramolecular dehydrative transformation to afford the title compounds.
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spelling pubmed-66485752019-08-27 Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3) Kolle, Shivalinga Barak, Dinesh S. Ghosh, Aritra Jaiswal, Vandana Kant, Ruchir Batra, Sanjay ACS Omega [Image: see text] A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl(3)-mediated intramolecular dehydrative transformation to afford the title compounds. American Chemical Society 2019-03-21 /pmc/articles/PMC6648575/ /pubmed/31459716 http://dx.doi.org/10.1021/acsomega.9b00396 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Kolle, Shivalinga
Barak, Dinesh S.
Ghosh, Aritra
Jaiswal, Vandana
Kant, Ruchir
Batra, Sanjay
Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title_full Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title_fullStr Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title_full_unstemmed Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title_short Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
title_sort dehydrative transformation of spirooxindoles to pyrido[2,3-b]indoles via pocl(3)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648575/
https://www.ncbi.nlm.nih.gov/pubmed/31459716
http://dx.doi.org/10.1021/acsomega.9b00396
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