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Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines

[Image: see text] Synthetic approaches toward multigram preparation of spirocyclic α,α-disubstituted pyrrolidines from readily available starting materials are discussed. It was shown that although a number of synthetic methodologies have been known to date, many of the title compounds remain hardly...

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Detalles Bibliográficos
Autores principales: Melnykov, Kostiantyn P., Artemenko, Artem N., Ivanenko, Bohdan O., Sokolenko, Yevhenii M., Nosik, Pavel S., Ostapchuk, Eugeniy N., Grygorenko, Oleksandr O., Volochnyuk, Dmitriy M., Ryabukhin, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648774/
https://www.ncbi.nlm.nih.gov/pubmed/31459845
http://dx.doi.org/10.1021/acsomega.9b00896