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Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines
[Image: see text] Synthetic approaches toward multigram preparation of spirocyclic α,α-disubstituted pyrrolidines from readily available starting materials are discussed. It was shown that although a number of synthetic methodologies have been known to date, many of the title compounds remain hardly...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648774/ https://www.ncbi.nlm.nih.gov/pubmed/31459845 http://dx.doi.org/10.1021/acsomega.9b00896 |