Cargando…
Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression
The eIF4E-homologous protein (4EHP) is a translational repressor that competes with eIF4E for binding to the 5′-cap structure of specific mRNAs, to which it is recruited by protein factors such as the GRB10-interacting GYF (glycine-tyrosine-phenylalanine domain) proteins (GIGYF). Several experimenta...
Autores principales: | Ruscica, Vincenzo, Bawankar, Praveen, Peter, Daniel, Helms, Sigrun, Igreja, Cátia, Izaurralde, Elisa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648886/ https://www.ncbi.nlm.nih.gov/pubmed/31114929 http://dx.doi.org/10.1093/nar/gkz429 |
Ejemplares similares
-
4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2
por: Amaya Ramirez, Cinthia C, et al.
Publicado: (2018) -
Molecular basis for GIGYF–Me31B complex assembly in 4EHP-mediated translational repression
por: Peter, Daniel, et al.
Publicado: (2019) -
GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression
por: Peter, Daniel, et al.
Publicado: (2017) -
A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay
por: Chang, Chung-Te, et al.
Publicado: (2019) -
Structure and dynamics of the quaternary hunchback mRNA translation repression complex
por: Macošek, Jakub, et al.
Publicado: (2021)