Dynamic Basis for Auranofin Drug Recognition by Thiol-Reductases of Human Pathogens and Intermediate Coordinated Adduct Formation with Catalytic Cysteine Residues

[Image: see text] In all the living systems, reactive oxygen species (ROS) metabolism provides resistance against internal and external oxidative stresses. Auranofin (AF), an FDA-approved gold [Au(I)]-conjugated drug, is known to selectively target thiol-reductases, key enzymes involved in ROS metab...

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Detalles Bibliográficos
Autores principales: Abhishek, Suman, Sivadas, Sreeragh, Satish, Mutyala, Deeksha, Waghela, Rajakumara, Eerappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649031/
https://www.ncbi.nlm.nih.gov/pubmed/31460050
http://dx.doi.org/10.1021/acsomega.9b00529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649031/
https://www.ncbi.nlm.nih.gov/pubmed/31460050
http://dx.doi.org/10.1021/acsomega.9b00529

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