The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

Cell growth is controlled by a lysosomal signaling complex containing Rag small GTPases and mTORC1 kinase. Here we carried out a microscopy-based genome-wide human siRNA screen and discovered a lysosome-localized G-protein coupled receptor (GPCR)-like protein, GPR137B, that interacts with Rag GTPase...

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Detalles Bibliográficos
Autores principales: Gan, Lin, Seki, Akiko, Shen, Kimberle, Iyer, Harini, Han, Kyuho, Hayer, Arnold, Wollman, Roy, Ge, Xuecai, Lin, Jerry, Dey, Gautam, Talbot, William S., Meyer, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649673/
https://www.ncbi.nlm.nih.gov/pubmed/31036939
http://dx.doi.org/10.1038/s41556-019-0321-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649673/
https://www.ncbi.nlm.nih.gov/pubmed/31036939
http://dx.doi.org/10.1038/s41556-019-0321-6

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