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Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers
BACKGROUND: It is often assumed any cancer in a germline BRCA1 or BRCA2 (collectively termed BRCA) mutation carrier was caused by that mutation. It is also often assumed the occurrence of breast or ovarian cancer in an individual with a variant of uncertain significance (VUS) suggests the VUS is pat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649772/ https://www.ncbi.nlm.nih.gov/pubmed/31360904 http://dx.doi.org/10.1093/jncics/pkz028 |