mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Antisense technology can reduce gene expression via the RNase H1 or RISC pathways and can increase gene expression through modulation of splicing or translation. Here, we demonstrate that antisense oligonucleotides (ASOs) can reduce mRNA levels by acting through the no-go decay pathway. Phosphorothi...

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Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Nichols, Joshua G, Hsu, Chih-Wei, Vickers, Timothy A, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649848/
https://www.ncbi.nlm.nih.gov/pubmed/31165876
http://dx.doi.org/10.1093/nar/gkz500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649848/
https://www.ncbi.nlm.nih.gov/pubmed/31165876
http://dx.doi.org/10.1093/nar/gkz500

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