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Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and analyses of interactions of key circadian proteins wi...

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Detalles Bibliográficos
Autores principales: Petkau, Nikolai, Budak, Harun, Zhou, Xunlei, Oster, Henrik, Eichele, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650244/
https://www.ncbi.nlm.nih.gov/pubmed/31294688
http://dx.doi.org/10.7554/eLife.43235