Phosphorylated Rho-GDP Directly Activates mTORC2 Kinase Toward AKT Through Dimerization with Ras-GTP to Regulate Cell Migration

mTORC2 plays critical roles in metabolism, cell survival, and actin cytoskeletal dynamics via phosphorylation of AKT. Despite its importance to biology and medicine, it is unclear how mTORC2-mediated AKT phosphorylation is controlled. Here, we identify an unforeseen principle by which a GDP-bound fo...

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Detalles Bibliográficos
Autores principales: Senoo, Hiroshi, Kamimura, Yoichiro, Kimura, Reona, Nakajima, Akihiko, Sawai, Satoshi, Sesaki, Hiromi, Iijima, Miho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650273/
https://www.ncbi.nlm.nih.gov/pubmed/31263268
http://dx.doi.org/10.1038/s41556-019-0348-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650273/
https://www.ncbi.nlm.nih.gov/pubmed/31263268
http://dx.doi.org/10.1038/s41556-019-0348-8

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