Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

Developmental silencing of fetal globins serves as both a paradigm of spatiotemporal gene regulation and an opportunity for β-hemoglobinopathy therapeutic intervention. The NuRD chromatin complex participates in γ-globin repression. Here we use pooled CRISPR screening to comprehensively disrupt NuRD...

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Detalles Bibliográficos
Autores principales: Sher, Falak, Hossain, Mir, Seruggia, Davide, Schoonenberg, Vivien A. C., Yao, Qiuming, Cifani, Paolo, Dassama, Laura M. K., Cole, Mitchel A., Ren, Chunyan, Vinjamur, Divya S., Macias-Trevino, Claudio, Luk, Kevin, McGuckin, Connor, Schupp, Patrick G., Canver, Matthew C., Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Wolfe, Scot A., Pinello, Luca, Maeda, Takahiro, Kentsis, Alex, Orkin, Stuart H., Bauer, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650275/
https://www.ncbi.nlm.nih.gov/pubmed/31253978
http://dx.doi.org/10.1038/s41588-019-0453-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650275/
https://www.ncbi.nlm.nih.gov/pubmed/31253978
http://dx.doi.org/10.1038/s41588-019-0453-4

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