Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP

Physical cues are vital in determining cellular fate in cancer. In vitro 3D culture do not replicate forces present in vivo. These forces including tumor interstitial fluid pressure and matrix stiffness behave as switches in differentiation and metastasis, which are intricate features of cancer stem...

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Detalles Bibliográficos
Autores principales: Arun, Raj Pranap, Sivanesan, Divya, Patra, Bamadeb, Varadaraj, Sudha, Verma, Rama Shanker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650394/
https://www.ncbi.nlm.nih.gov/pubmed/31337825
http://dx.doi.org/10.1038/s41598-019-47116-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650394/
https://www.ncbi.nlm.nih.gov/pubmed/31337825
http://dx.doi.org/10.1038/s41598-019-47116-5

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