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Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
Physical cues are vital in determining cellular fate in cancer. In vitro 3D culture do not replicate forces present in vivo. These forces including tumor interstitial fluid pressure and matrix stiffness behave as switches in differentiation and metastasis, which are intricate features of cancer stem...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650394/ https://www.ncbi.nlm.nih.gov/pubmed/31337825 http://dx.doi.org/10.1038/s41598-019-47116-5 |