Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13

Numerous mutations in the Plasmodium falciparum Kelch13 (K13) protein confer resistance to artemisinin derivatives, the current front-line antimalarial drugs. K13 is an essential protein that contains BTB and Kelch-repeat propeller (KREP) domains usually found in E3 ubiquitin ligase complexes that t...

Descripción completa

Detalles Bibliográficos
Autores principales: Coppée, Romain, Jeffares, Daniel C., Miteva, Maria A., Sabbagh, Audrey, Clain, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650413/
https://www.ncbi.nlm.nih.gov/pubmed/31337835
http://dx.doi.org/10.1038/s41598-019-47034-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650413/
https://www.ncbi.nlm.nih.gov/pubmed/31337835
http://dx.doi.org/10.1038/s41598-019-47034-6

Ejemplares similares