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Augmentation of myocardial I(f) dysregulates calcium homeostasis and causes adverse cardiac remodeling
HCN channels underlie the depolarizing funny current (I(f)) that contributes importantly to cardiac pacemaking. I(f) is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mice (HCN4(tg/wt)) to assess functional conseque...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650438/ https://www.ncbi.nlm.nih.gov/pubmed/31337768 http://dx.doi.org/10.1038/s41467-019-11261-2 |