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Augmentation of myocardial I(f) dysregulates calcium homeostasis and causes adverse cardiac remodeling

HCN channels underlie the depolarizing funny current (I(f)) that contributes importantly to cardiac pacemaking. I(f) is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mice (HCN4(tg/wt)) to assess functional conseque...

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Detalles Bibliográficos
Autores principales:	Yampolsky, Pessah, Koenen, Michael, Mosqueira, Matias, Geschwill, Pascal, Nauck, Sebastian, Witzenberger, Monika, Seyler, Claudia, Fink, Thomas, Kruska, Mathieu, Bruehl, Claus, Schwoerer, Alexander P., Ehmke, Heimo, Fink, Rainer H. A., Draguhn, Andreas, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650438/ https://www.ncbi.nlm.nih.gov/pubmed/31337768 http://dx.doi.org/10.1038/s41467-019-11261-2

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