Loss of Ku’s DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis

Saccharomyces cerevisiae telomerase, which maintains telomere length, is comprised of an RNA component, TLC1, the reverse transcriptase, Est2, and regulatory subunits, including Est1. The Yku70/Yku80 (Ku) heterodimer, a DNA end binding (DEB) protein, also contributes to telomere length maintenance....

Descripción completa

Detalles Bibliográficos
Autores principales: Lemon, Laramie D., Morris, Danna K., Bertuch, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650470/
https://www.ncbi.nlm.nih.gov/pubmed/31337791
http://dx.doi.org/10.1038/s41598-019-46840-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650470/
https://www.ncbi.nlm.nih.gov/pubmed/31337791
http://dx.doi.org/10.1038/s41598-019-46840-2

Ejemplares similares