An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells

Constraint-based modeling has been applied to analyze metabolism of numerous organisms via flux balance analysis and genome-scale metabolic models, including mammalian cells such as the Chinese hamster ovary (CHO) cells—the principal cell factory platform for therapeutic protein production. Unfortun...

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Detalles Bibliográficos
Autores principales: Chen, Yiqun, McConnell, Brian O., Gayatri Dhara, Venkata, Mukesh Naik, Harnish, Li, Chien-Ting, Antoniewicz, Maciek R., Betenbaugh, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650483/
https://www.ncbi.nlm.nih.gov/pubmed/31341637
http://dx.doi.org/10.1038/s41540-019-0103-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650483/
https://www.ncbi.nlm.nih.gov/pubmed/31341637
http://dx.doi.org/10.1038/s41540-019-0103-6

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