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An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells
Constraint-based modeling has been applied to analyze metabolism of numerous organisms via flux balance analysis and genome-scale metabolic models, including mammalian cells such as the Chinese hamster ovary (CHO) cells—the principal cell factory platform for therapeutic protein production. Unfortun...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650483/ https://www.ncbi.nlm.nih.gov/pubmed/31341637 http://dx.doi.org/10.1038/s41540-019-0103-6 |