Cargando…

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

The filoviruses are etiological agents of life-threatening hemorrhagic fever with high mortality rate and risk of potential outbreak. Among members of this family, the Ebola (EBOV), Sudan (SUDV), and Marburg (MARV) viruses are considered the most pathogenic for humans. The ebolavirus nucleoprotein (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Landeras-Bueno, Sara, Oda, Shun-ichiro, Norris, Michael J., Li Salie, Zhe, Guenaga, Javier, Wyatt, Richard T., Saphire, Erica Ollmann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650547/ https://www.ncbi.nlm.nih.gov/pubmed/31337716 http://dx.doi.org/10.1128/mBio.00734-19

Ejemplares similares

Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors
por: Bramble, Matthew S, et al.
Publicado: (2018)

Ebolavirus and Other Filoviruses
por: Leroy, E., et al.
Publicado: (2007)

Structure of the Reston ebolavirus VP30 C-terminal domain
por: Clifton, Matthew C., et al.
Publicado: (2014)

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form
por: Landeras-Bueno, Sara, et al.
Publicado: (2021)

Discovery of an Ebolavirus-Like Filovirus in Europe
por: Negredo, Ana, et al.
Publicado: (2011)

Development and Structural Analysis of Antibody Therapeutics for Filoviruses
por: Yu, Xiaoying, et al.
Publicado: (2022)

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
por: Kirchdoerfer, Robert N., et al.
Publicado: (2016)

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein
por: Gilchuk, Pavlo, et al.
Publicado: (2018)

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope
por: West, Brandyn R., et al.
Publicado: (2018)

Characterization of Sudan Ebolavirus infection in ferrets
por: Kroeker, Andrea, et al.
Publicado: (2017)

Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology
por: Johnson, Reed F, et al.
Publicado: (2006)

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
por: Ng, Melinda, et al.
Publicado: (2015)

Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo
por: Shaffer, Kelly C. L., et al.
Publicado: (2022)

Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor
por: Kondoh, Tatsunari, et al.
Publicado: (2017)

Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity
por: Flego, Michela, et al.
Publicado: (2019)

Structural Basis for Differential Neutralization of Ebolaviruses
por: Bale, Shridhar, et al.
Publicado: (2012)

dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35
por: Zinzula, Luca, et al.
Publicado: (2012)

133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions
por: Bornholdt, Zachary, et al.
Publicado: (2014)

Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24
por: Ramanathan, Palaniappan, et al.
Publicado: (2023)

Discovery of an antibody for pan-ebolavirus therapy
por: Furuyama, Wakako, et al.
Publicado: (2016)

Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs
por: Shepley-McTaggart, Ariel, et al.
Publicado: (2021)

Natural history of Sudan ebolavirus infection in rhesus and cynomolgus macaques
por: Woolsey, Courtney, et al.
Publicado: (2022)

Natural History of Sudan ebolavirus to Support Medical Countermeasure Development
por: Carbonnelle, Caroline, et al.
Publicado: (2022)

A Shared Structural Solution for Neutralizing Ebolaviruses
por: Dias, João M., et al.
Publicado: (2011)

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry
por: Schafer, Adam, et al.
Publicado: (2021)

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease
por: Hastie, Kathryn M., et al.
Publicado: (2012)

Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus
por: Wolfe, Daniel N., et al.
Publicado: (2020)

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a Pan-Ebolavirus Immunotherapeutic
por: Kuang, Erin, et al.
Publicado: (2022)

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers
por: Wan, William, et al.
Publicado: (2020)

Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
por: Murin, Charles D., et al.
Publicado: (2022)

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism
por: Bale, Shridhar, et al.
Publicado: (2012)

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses
por: Manhart, Whitney A., et al.
Publicado: (2018)

Dendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection
por: Edenborough, Kathryn M., et al.
Publicado: (2019)

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
por: King, Liam B., et al.
Publicado: (2019)

Re-emergence of Sudan ebolavirus after a decade: new challenge to Ebola control
por: Sah, Ranjit, et al.
Publicado: (2023)

Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants
por: Shu, Qingbo, et al.
Publicado: (2021)

Glycan shield of the ebolavirus envelope glycoprotein GP
por: Peng, Weiwei, et al.
Publicado: (2022)

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody
por: West, Brandyn R., et al.
Publicado: (2019)

Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses
por: Lehrer, Axel T., et al.
Publicado: (2021)

Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge
por: Chen, Gang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uc8knro9jd8nqsvb4qgiubr7b4