Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA

The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The interferon-inducible protein 16 (IFI16) is a viral DNA sensor th...

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Detalles Bibliográficos
Autores principales: Lum, Krystal K., Howard, Timothy R., Pan, Catherina, Cristea, Ileana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650555/
https://www.ncbi.nlm.nih.gov/pubmed/31337724
http://dx.doi.org/10.1128/mBio.01428-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650555/
https://www.ncbi.nlm.nih.gov/pubmed/31337724
http://dx.doi.org/10.1128/mBio.01428-19

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