A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration

Background: rs9357347 located at the triggering receptor expressed on myeloid cells (TREM) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer’s disease (AD). Objectives: To investigate the role...

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Detalles Bibliográficos
Autores principales: Tian, Mei-Ling, Ni, Xiao-Neng, Li, Jie-Qiong, Tan, Chen-Chen, Cao, Xi-Peng, Tan, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650562/
https://www.ncbi.nlm.nih.gov/pubmed/31379492
http://dx.doi.org/10.3389/fnins.2019.00742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650562/
https://www.ncbi.nlm.nih.gov/pubmed/31379492
http://dx.doi.org/10.3389/fnins.2019.00742

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