Computational Investigation of Bisphosphate Inhibitors of 3-Deoxy-d-manno-octulosonate 8-phosphate Synthase

The synthase, 3-deoxy-d-manno-octulosonate 8-phosphate (KDO8P), is a key enzyme for the lipopolysaccharide (LPS) biosynthesis of gram-negative bacteria and a potential target for developing new antimicrobial agents. In this study, computational molecular modeling methods were used to determine the c...

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Detalles Bibliográficos
Autores principales: Araújo, Jéssica de Oliveira, dos Santos, Alberto Monteiro, Lameira, Jerônimo, Alves, Cláudio Nahum, Lima, Anderson Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650799/
https://www.ncbi.nlm.nih.gov/pubmed/31252580
http://dx.doi.org/10.3390/molecules24132370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650799/
https://www.ncbi.nlm.nih.gov/pubmed/31252580
http://dx.doi.org/10.3390/molecules24132370

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