Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions

A novel flow-based approach for the preparation of benzimidazol-2-one (1) scaffold by the 1,1′-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of o-phenylenediamine (2) is reported. Starting from a preliminary batch screening, the model reaction was successfully translated under flow condition...

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Detalles Bibliográficos
Autores principales: Mostarda, Serena, Gür Maz, Tugçe, Piccinno, Alessandro, Cerra, Bruno, Banoglu, Erden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651037/
https://www.ncbi.nlm.nih.gov/pubmed/31277341
http://dx.doi.org/10.3390/molecules24132447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651037/
https://www.ncbi.nlm.nih.gov/pubmed/31277341
http://dx.doi.org/10.3390/molecules24132447

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