The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a key role in the epigenetic regulation of tissue homeostasis...

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Detalles Bibliográficos
Autores principales: Alves-Fernandes, Débora Kristina, Jasiulionis, Miriam Galvonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651129/
https://www.ncbi.nlm.nih.gov/pubmed/31261609
http://dx.doi.org/10.3390/ijms20133153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651129/
https://www.ncbi.nlm.nih.gov/pubmed/31261609
http://dx.doi.org/10.3390/ijms20133153

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