Cargando…

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a key role in the epigenetic regulation of tissue homeostasis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alves-Fernandes, Débora Kristina, Jasiulionis, Miriam Galvonas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651129/ https://www.ncbi.nlm.nih.gov/pubmed/31261609 http://dx.doi.org/10.3390/ijms20133153

Ejemplares similares

Epigenetic Regulation in Sepsis, Role in Pathophysiology and Therapeutic Perspective
por: Falcão-Holanda, Renata Brito, et al.
Publicado: (2021)

Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer
por: Justo, Beatriz Laís, et al.
Publicado: (2021)

The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation
por: Gasque Schoof, Cláudia Regina, et al.
Publicado: (2015)

The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin
por: Gonçalves, Diego Assis, et al.
Publicado: (2021)

miRNAs and Melanoma: How Are They Connected?
por: da Cruz, Adriana Taveira, et al.
Publicado: (2012)

Editorial: The functions of extracellular vesicles in melanoma
por: García-Silva, Susana, et al.
Publicado: (2023)

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis
por: Benito-Martín, Alberto, et al.
Publicado: (2023)

Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases
por: de Souza, Camila Ferreira, et al.
Publicado: (2012)

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma
por: Gujar, Hemant, et al.
Publicado: (2021)

Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
por: Molognoni, Fernanda, et al.
Publicado: (2013)

Correction: Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
por: Molognoni, Fernanda, et al.
Publicado: (2015)

Abnormal Epigenetic Regulation of Immune System during Aging
por: Jasiulionis, Miriam G.
Publicado: (2018)

Modification of Epigenetic Patterns in Low Birth Weight Children: Importance of Hypomethylation of the ACE Gene Promoter
por: Rangel, Marina, et al.
Publicado: (2014)

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
por: Kala, Rishabh, et al.
Publicado: (2015)

Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
por: Debelec-Butuner, Bilge, et al.
Publicado: (2015)

Thallium-induced DNA damage, genetic, and epigenetic alterations
por: Sánchez-Chapul, Laura, et al.
Publicado: (2023)

Role of some epigenetic factors in DNA damage response pathway
por: Tiwari, Mrinalini, et al.
Publicado: (2017)

Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor
por: Bachi, André Luis Lacerda, et al.
Publicado: (2012)

Targeting the epigenetics of the DNA damage response in breast cancer
por: Montenegro, M F, et al.
Publicado: (2016)

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
por: Meng, Fanbiao, et al.
Publicado: (2020)

Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response
por: Ouyang, Chenxi, et al.
Publicado: (2022)

SIRT1 regulates Mxd1 during malignant melanoma progression
por: Meliso, Fabiana M., et al.
Publicado: (2017)

SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
por: Luna, Augustin, et al.
Publicado: (2013)

Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression
por: Nevoral, Jan, et al.
Publicado: (2019)

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation
por: Kilic Eren, Mehtap, et al.
Publicado: (2015)

Epigenetics, DNA damage, and aging
por: Soto-Palma, Carolina, et al.
Publicado: (2022)

Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients
por: Papaiz, Debora D’Angelo, et al.
Publicado: (2022)

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage
por: Rizzo, Angela, et al.
Publicado: (2017)

Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry
por: de Melo, Fabiana Henriques Machado, et al.
Publicado: (2021)

Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification
por: Bartoli-Leonard, Francesca, et al.
Publicado: (2020)

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
por: Oikemus, Sarah R, et al.
Publicado: (2006)

Sirtuins and DNA damage repair: SIRT7 comes to play
por: Vazquez, Berta N., et al.
Publicado: (2017)

Mining Gene Expression Signature for the Detection of Pre-Malignant Melanocytes and Early Melanomas with Risk for Metastasis
por: de Souza, Camila Ferreira, et al.
Publicado: (2012)

DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations
por: Kgatle, Mankgopo Magdeline, et al.
Publicado: (2017)

CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
por: Kang, Hyeog, et al.
Publicado: (2009)

Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response
por: Kwon, Jiyun, et al.
Publicado: (2019)

miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients
por: da Cruz, Adriana Taveira, et al.
Publicado: (2021)

DNA Damage: Epigenetics, Aging and Rejuvenation
por: Sinclair, David
Publicado: (2020)

Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?
por: Lazo, Pedro A.
Publicado: (2022)

Brothers in arms: emerging roles of RNA epigenetics in DNA damage repair
por: Zhang, Jinwei
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g673vmlk1i6j2iu7161hgpd31f