Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG

Human ether-a-gogo related gene (hERG) product is the membrane potassium channel Kv11.1, which is involved in the electrical activity of the heart. As such, it is a key player in the toxicity of many drug candidates. Therefore, having this protein at hand during earlier stages of drug discovery is i...

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Detalles Bibliográficos
Autores principales: Vasseur, Lucie, Cens, Thierry, Wagner, Renaud, Saint, Nathalie, Kugler, Valérie, Chavanieu, Alain, Ouvry, Christine, Dupré, Clémence, Ferry, Gilles, Boutin, Jean A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651182/
https://www.ncbi.nlm.nih.gov/pubmed/31261773
http://dx.doi.org/10.3390/ijms20133181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651182/
https://www.ncbi.nlm.nih.gov/pubmed/31261773
http://dx.doi.org/10.3390/ijms20133181

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