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Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG
Human ether-a-gogo related gene (hERG) product is the membrane potassium channel Kv11.1, which is involved in the electrical activity of the heart. As such, it is a key player in the toxicity of many drug candidates. Therefore, having this protein at hand during earlier stages of drug discovery is i...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651182/ https://www.ncbi.nlm.nih.gov/pubmed/31261773 http://dx.doi.org/10.3390/ijms20133181 |