Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes

The vicious itch–scratch cycle is a cardinal feature of atopic dermatitis (AD), in which IL-13 signaling plays a dominant role. Keratinocytes express two receptors: The heterodimeric IL-4Rα/IL-13Rα1 and IL-13Rα2. The former one transduces a functional IL-13 signal, whereas the latter IL-13Rα2 works...

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Detalles Bibliográficos
Autores principales: Ulzii, Dugarmaa, Kido-Nakahara, Makiko, Nakahara, Takeshi, Tsuji, Gaku, Furue, Kazuhisa, Hashimoto-Hachiya, Akiko, Furue, Masutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651282/
https://www.ncbi.nlm.nih.gov/pubmed/31284553
http://dx.doi.org/10.3390/ijms20133324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651282/
https://www.ncbi.nlm.nih.gov/pubmed/31284553
http://dx.doi.org/10.3390/ijms20133324

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