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Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atr...

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Detalles Bibliográficos
Autores principales: Chan, Chao-Shun, Lin, Yung-Kuo, Chen, Yao-Chang, Lu, Yen-Yu, Chen, Shih-Ann, Chen, Yi-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651382/
https://www.ncbi.nlm.nih.gov/pubmed/31262061
http://dx.doi.org/10.3390/ijms20133224