Cargando…

Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Chao-Shun, Lin, Yung-Kuo, Chen, Yao-Chang, Lu, Yen-Yu, Chen, Shih-Ann, Chen, Yi-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651382/ https://www.ncbi.nlm.nih.gov/pubmed/31262061 http://dx.doi.org/10.3390/ijms20133224

Ejemplares similares

Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole
por: Ye, Wenduo, et al.
Publicado: (2015)

Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity
por: Groenke, Sabine, et al.
Publicado: (2013)

Pacemaker Synchronization of Electrically Coupled Rabbit Sinoatrial Node Cells
por: Verheijck, E. Etienne, et al.
Publicado: (1998)

Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells?
por: Zhou, Bin
Publicado: (2021)

Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons
por: Liang, Dandan, et al.
Publicado: (2021)

Pregnancy and oestrogen regulate sinoatrial node calcium homeostasis and accelerate pacemaking
por: El Khoury, Nabil, et al.
Publicado: (2018)

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
por: Easterling, Marietta, et al.
Publicado: (2021)

Atrial and Sinoatrial Node Development in the Zebrafish Heart
por: Martin, Kendall E., et al.
Publicado: (2021)

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell
por: Yaniv, Yael, et al.
Publicado: (2015)

Drivers of Sinoatrial Node Automaticity in Zebrafish: Comparison With Mechanisms of Mammalian Pacemaker Function
por: Stoyek, Matthew R., et al.
Publicado: (2022)

Pulsed field ablation of incessant superior vena cava–triggered atrial fibrillation: watch out for the sinoatrial node
por: Chen, Shaojie, et al.
Publicado: (2023)

Three-dimensional electroanatomic mapping characteristics of superior vena cava myocardial sleeve and sinoatrial node in patients with atrial fibrillation
por: Chen, Xinguang, et al.
Publicado: (2022)

Intracellular Na(+) Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis
por: Morotti, Stefano, et al.
Publicado: (2021)

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node
por: Mandla, Ravi, et al.
Publicado: (2021)

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation
por: Ramos-Mondragon, Roberto, et al.
Publicado: (2022)

In silico study of the effects of anti-arrhythmic drug treatment on sinoatrial node function for patients with atrial fibrillation
por: Bai, Jieyun, et al.
Publicado: (2020)

Function and Dysfunction of Human Sinoatrial Node
por: Joung, Boyoung, et al.
Publicado: (2015)

Hyperpolarization-Activated Current, I (f), in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
por: Verkerk, Arie O., et al.
Publicado: (2013)

Cyclic AMP reverses the effects of aging on pacemaker activity and I(f) in sinoatrial node myocytes
por: Sharpe, Emily J., et al.
Publicado: (2017)

HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node
por: Kozasa, Yuko, et al.
Publicado: (2018)

Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells
por: Verkerk, Arie O., et al.
Publicado: (2013)

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current
por: Verkerk, Arie O., et al.
Publicado: (2015)

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking
por: Unudurthi, Sathya D., et al.
Publicado: (2014)

The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition
por: Liu, Ruxiu, et al.
Publicado: (2018)

Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models
por: Campana, Chiara, et al.
Publicado: (2022)

Telocytes in the human sinoatrial node
por: Mitrofanova, Lubov B., et al.
Publicado: (2017)

Hydrogen sulphide increases pulmonary veins and atrial arrhythmogenesis with activation of protein kinase C
por: Chan, Chao‐Shun, et al.
Publicado: (2018)

The Calcium and Voltage Clocks in Sinoatrial Node Automaticity
por: Joung, Boyoung, et al.
Publicado: (2009)

Epicardial ablation of a focal atrial tachycardia adjacent to the sinoatrial node: A case report
por: Chen, Yanhong, et al.
Publicado: (2022)

Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity
por: Turner, Daniel, et al.
Publicado: (2021)

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix
por: Gluck, Jessica M., et al.
Publicado: (2017)

cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
por: Fenske, Stefanie, et al.
Publicado: (2020)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome
por: Lang, Di, et al.
Publicado: (2021)

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue
por: Maltsev, Alexander V., et al.
Publicado: (2022)

Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K(+) Current, I(Ks)
por: Verkerk, Arie O., et al.
Publicado: (2023)

Distinct Patterns of Constitutive Phosphodiesterase Activity in Mouse Sinoatrial Node and Atrial Myocardium
por: Hua, Rui, et al.
Publicado: (2012)

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis
por: Tuomi, Jari M., et al.
Publicado: (2021)

The Role of the Calcium and the Voltage Clocks in Sinoatrial Node Dysfunction
por: Joung, Boyoung, et al.
Publicado: (2011)

Genetic Complexity of Sinoatrial Node Dysfunction
por: Wallace, Michael J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ar2d85v92uilnv6173irsnjs79