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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant activation of the NLRP3 inflammasome has been linked...
Autores principales: | Kelley, Nathan, Jeltema, Devon, Duan, Yanhui, He, Yuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651423/ https://www.ncbi.nlm.nih.gov/pubmed/31284572 http://dx.doi.org/10.3390/ijms20133328 |
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