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SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes

Hereditary Parkinson’s disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We demonstrated the combination of PINK1-knockout with overexpress...

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Detalles Bibliográficos
Autores principales: Auburger, Georg, Gispert, Suzana, Torres-Odio, Sylvia, Jendrach, Marina, Brehm, Nadine, Canet-Pons, Júlia, Key, Jana, Sen, Nesli-Ece
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651490/
https://www.ncbi.nlm.nih.gov/pubmed/31277379
http://dx.doi.org/10.3390/ijms20133284