Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations. These mutations in specific genes generate premature termination codons (PTCs) respons...

Descripción completa

Detalles Bibliográficos
Autores principales: Campofelice, Ambra, Lentini, Laura, Di Leonardo, Aldo, Melfi, Raffaella, Tutone, Marco, Pace, Andrea, Pibiri, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651739/
https://www.ncbi.nlm.nih.gov/pubmed/31284579
http://dx.doi.org/10.3390/ijms20133329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651739/
https://www.ncbi.nlm.nih.gov/pubmed/31284579
http://dx.doi.org/10.3390/ijms20133329

Ejemplares similares