Cargando…

Activation of the IGF Axis in Thyroid Cancer: Implications for Tumorigenesis and Treatment

The Insulin-like growth factor (IGF) axis is one of the best-established drivers of thyroid transformation, as thyroid cancer cells overexpress both IGF ligands and their receptors. Thyroid neoplasms encompass distinct clinical and biological entities as differentiated thyroid carcinomas (DTC)—compr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manzella, Livia, Massimino, Michele, Stella, Stefania, Tirrò, Elena, Pennisi, Maria Stella, Martorana, Federica, Motta, Gianmarco, Vitale, Silvia Rita, Puma, Adriana, Romano, Chiara, Di Gregorio, Sandra, Russo, Marco, Malandrino, Pasqualino, Vigneri, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651760/ https://www.ncbi.nlm.nih.gov/pubmed/31269742 http://dx.doi.org/10.3390/ijms20133258

Ejemplares similares

Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice
por: Tirrò, Elena, et al.
Publicado: (2019)

The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy
por: Vigneri, Paolo Giovanni, et al.
Publicado: (2015)

Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma
por: Tirrò, Elena, et al.
Publicado: (2021)

New Insights in Thyroid Cancer and p53 Family Proteins
por: Manzella, Livia, et al.
Publicado: (2017)

Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer
por: Romano, Chiara, et al.
Publicado: (2021)

Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes
por: Stella, Stefania, et al.
Publicado: (2021)

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts
por: Massimino, Michele, et al.
Publicado: (2021)

Non ABL-directed inhibitors as alternative treatment strategies for chronic myeloid leukemia
por: Massimino, Michele, et al.
Publicado: (2018)

A Novel System for Semiautomatic Sample Processing in Chronic Myeloid Leukaemia: Increasing Throughput without Impacting on Molecular Monitoring at Time of SARS-CoV-2 Pandemic
por: Stella, Stefania, et al.
Publicado: (2021)

Potential Therapeutic Targets for Luminal Androgen Receptor Breast Cancer: What We Know so Far
por: Stella, Stefania, et al.
Publicado: (2023)

AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?
por: Martorana, Federica, et al.
Publicado: (2021)

Impact of Different Cell Counting Methods in Molecular Monitoring of Chronic Myeloid Leukemia Patients
por: Stella, Stefania, et al.
Publicado: (2022)

Single-Cell Analysis in the Omics Era: Technologies and Applications in Cancer
por: Massimino, Michele, et al.
Publicado: (2023)

High BCR::ABL1 Expression Defines CD34+ Cells with Significant Alterations in Signal Transduction, Short-Proliferative Potential and Self-Renewal Ability
por: Massimino, Michele, et al.
Publicado: (2023)

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells
por: Stella, Stefania, et al.
Publicado: (2023)

Combined Inhibition of Bcl2 and Bcr-Abl1 Exercises Anti-Leukemia Activity but Does Not Eradicate the Primitive Leukemic Cells
por: Massimino, Michele, et al.
Publicado: (2021)

BCR-ABL1 Doubling-Times and Halving-Times May Predict CML Response to Tyrosine Kinase Inhibitors
por: Pennisi, Maria Stella, et al.
Publicado: (2019)

The other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities
por: Stella, Stefania, et al.
Publicado: (2021)

Chk1 Inhibition Restores Inotuzumab Ozogamicin Citotoxicity in CD22-Positive Cells Expressing Mutant p53
por: Tirrò, Elena, et al.
Publicado: (2019)

Additional Genetic Alterations and Clonal Evolution of MPNs with Double Mutations on the MPL Gene: Two Case Reports
por: Pennisi, Maria Stella, et al.
Publicado: (2023)

Clinical Implications of Discordant Early Molecular Responses in CML Patients Treated with Imatinib
por: Stella, Stefania, et al.
Publicado: (2019)

Mutational Analysis of BRCA1 and BRCA2 Genes in Breast Cancer Patients from Eastern Sicily
por: Stella, Stefania, et al.
Publicado: (2022)

A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications
por: Tirrò, Elena, et al.
Publicado: (2022)

A New Kid on the Block: Sacituzumab Govitecan for the Treatment of Breast Cancer and Other Solid Tumors
por: Pavone, Giuliana, et al.
Publicado: (2021)

Increased Thyroid Cancer Incidence in Volcanic Areas: A Role of Increased Heavy Metals in the Environment?
por: Malandrino, Pasqualino, et al.
Publicado: (2020)

Heavy Metals in the Environment and Thyroid Cancer
por: Gianì, Fiorenza, et al.
Publicado: (2021)

IRF5 promotes the proliferation of human thyroid cancer cells
por: Massimino, Michele, et al.
Publicado: (2012)

Corticosteroid Pulse Therapy for Graves' Ophthalmopathy Reduces the Relapse Rate of Graves' Hyperthyroidism
por: Le Moli, Rosario, et al.
Publicado: (2020)

Editorial: The role of the IGF axis in tumorigenesis and cancer treatment: From genes to metabolites
por: Mengzhe, Guo, et al.
Publicado: (2023)

Prognostic Factors for Adrenocortical Carcinoma Outcomes
por: Scollo, Claudia, et al.
Publicado: (2016)

Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics
por: Tavarelli, Martina, et al.
Publicado: (2017)

Descriptive Epidemiology of Human Thyroid Cancer: Experience From a Regional Registry and The “Volcanic Factor”
por: Malandrino, Pasqualino, et al.
Publicado: (2013)

Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation
por: Luca, Emilia, et al.
Publicado: (2017)

Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature
por: Pavone, Giuliana, et al.
Publicado: (2022)

Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases
por: Martorana, Federica, et al.
Publicado: (2021)

Different FT3/TSH correlation in acquired and congenital hypothyroid patients reveals a different hypothalamic set‐point
por: Russo, Marco, et al.
Publicado: (2022)

Therapeutic Targeting of the IGF Axis
por: Osher, Eliot, et al.
Publicado: (2019)

Role of FGF System in Neuroendocrine Neoplasms: Potential Therapeutic Applications
por: Vitale, Giovanni, et al.
Publicado: (2021)

The Multiple Faces of the GH/IGF Axis
por: Chesnokova, Vera
Publicado: (2022)

Diagnostic Utility of the Immunohistochemical Expression of Serine and Arginine Rich Splicing Factor 1 (SRSF1) in the Differential Diagnosis of Adult Gliomas
por: Broggi, Giuseppe, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_khu2u6eb3s0fe38260b3eqtab4