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Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma
BACKGROUND: The cancer-associated fibroblast (CAF) population is implicated in immune dysregulation. Here, we test the hypothesis that CAF profiles in pretreatment tumor specimens are associated with response to immune checkpoint blockade of programmed cell death 1 (PD-1). METHODS: Pretreatment whol...
Autores principales: | Wong, Pok Fai, Wei, Wei, Gupta, Swati, Smithy, James W., Zelterman, Daniel, Kluger, Harriet M., Rimm, David L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651990/ https://www.ncbi.nlm.nih.gov/pubmed/31337426 http://dx.doi.org/10.1186/s40425-019-0675-0 |
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