Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

BACKGROUND: Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular h...

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Detalles Bibliográficos
Autores principales: Hippensteel, Joseph A., Uchimido, Ryo, Tyler, Patrick D., Burke, Ryan C., Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A., Colbert, James F., Lindsell, Christopher J., Angus, Derek C., Kellum, John A., Yealy, Donald M., Linhardt, Robert J., Shapiro, Nathan I., Schmidt, Eric P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://www.ncbi.nlm.nih.gov/pubmed/31337421
http://dx.doi.org/10.1186/s13054-019-2534-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://www.ncbi.nlm.nih.gov/pubmed/31337421
http://dx.doi.org/10.1186/s13054-019-2534-2

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