Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans

Drug-induced liver injury (DILI) is one of the most serious and frequent drug-related adverse events in humans. Selenium (Se) and glutathione (GSH) have a crucial role for the hepatoprotective effect against reactive metabolites or oxidative damage leading to DILI. The hepatoprotective capacity rela...

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Detalles Bibliográficos
Autores principales: Goda, Keisuke, Muta, Kyotaka, Yasui, Yuzo, Oshida, Shin-ichi, Kitatani, Kanae, Takekoshi, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652140/
https://www.ncbi.nlm.nih.gov/pubmed/31252607
http://dx.doi.org/10.3390/ijms20133141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652140/
https://www.ncbi.nlm.nih.gov/pubmed/31252607
http://dx.doi.org/10.3390/ijms20133141

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