Vaccination against Clostridium difficile by Use of an Attenuated Salmonella enterica Serovar Typhimurium Vector (YS1646) Protects Mice from Lethal Challenge

Clostridium difficile disease is mediated primarily by toxins A and B (TcdA and TcdB, respectively). The receptor binding domains (RBD) of TcdA and TcdB are immunogenic, and anti-RBD antibodies are protective. Since these toxins act locally, an optimal C. difficile vaccine would generate both system...

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Detalles Bibliográficos
Autores principales: Winter, Kaitlin, Xing, Li, Kassardjian, Audrey, Ward, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652760/
https://www.ncbi.nlm.nih.gov/pubmed/31138615
http://dx.doi.org/10.1128/IAI.00089-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652760/
https://www.ncbi.nlm.nih.gov/pubmed/31138615
http://dx.doi.org/10.1128/IAI.00089-19

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