The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis. Here, we found that TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl)-2-thienyl]acetic acid) was a novel inhibitor for GlmU acety...

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Detalles Bibliográficos
Autores principales: Chen, Changming, Han, Xiuyan, Yan, Qiulong, Wang, Chao, Jia, Liqiu, Taj, Ayaz, Zhao, Lizhe, Ma, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652808/
https://www.ncbi.nlm.nih.gov/pubmed/31380295
http://dx.doi.org/10.3389/fcimb.2019.00251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652808/
https://www.ncbi.nlm.nih.gov/pubmed/31380295
http://dx.doi.org/10.3389/fcimb.2019.00251

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