Cargando…

The urokinase‐type plasminogen activator system as drug target in retinitis pigmentosa: New pre‐clinical evidence in the rd10 mouse model

Retinitis pigmentosa (RP) is characterized by progressive loss of vision due to photoreceptor degeneration leading to secondary inflammation. The urokinase‐type plasminogen activator (uPA) system contributes to retinal inflammation, but its role in RP is unknown. In the rd10 mouse model of RP, we ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cammalleri, Maurizio, Dal Monte, Massimo, Locri, Filippo, Pecci, Valeria, De Rosa, Mario, Pavone, Vincenzo, Bagnoli, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653070/ https://www.ncbi.nlm.nih.gov/pubmed/31251468 http://dx.doi.org/10.1111/jcmm.14391

Ejemplares similares

Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System
por: Cammalleri, Maurizio, et al.
Publicado: (2017)

Inhibiting the urokinase‐type plasminogen activator receptor system recovers STZ‐induced diabetic nephropathy
por: Dal Monte, Massimo, et al.
Publicado: (2018)

Novel Insights into Beta 2 Adrenergic Receptor Function in the rd10 Model of Retinitis Pigmentosa
por: Cammalleri, Maurizio, et al.
Publicado: (2020)

Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury
por: Locri, Filippo, et al.
Publicado: (2019)

The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy
por: Cammalleri, Maurizio, et al.
Publicado: (2017)

Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration
por: Cammalleri, Maurizio, et al.
Publicado: (2017)

Further Evidence on Efficacy of Diet Supplementation with Fatty Acids in Ocular Pathologies: Insights from the EAE Model of Optic Neuritis
por: Locri, Filippo, et al.
Publicado: (2018)

UPARANT is an effective antiangiogenic agent in a mouse model of rubeosis iridis
por: Locri, Filippo, et al.
Publicado: (2019)

Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis
por: Dal Monte, Massimo, et al.
Publicado: (2018)

Gaining insight on mitigation of rubeosis iridis by UPARANT in a mouse model associated with proliferative retinopathy
por: Locri, Filippo, et al.
Publicado: (2020)

The uPAR System as a Potential Therapeutic Target in the Diseased Eye
por: Cammalleri, Maurizio, et al.
Publicado: (2019)

Potential role of the methylation of VEGF gene promoter in response to hypoxia in oxygen‐induced retinopathy: beneficial effect of the absence of AQP4
por: Pisani, Francesco, et al.
Publicado: (2017)

A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma
por: Cammalleri, Maurizio, et al.
Publicado: (2020)

Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma
por: Melecchi, Alberto, et al.
Publicado: (2023)

Preventive Efficacy of an Antioxidant Compound on Blood Retinal Barrier Breakdown and Visual Dysfunction in Streptozotocin-Induced Diabetic Rats
por: Canovai, Alessio, et al.
Publicado: (2022)

Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors
por: Filippi, Luca, et al.
Publicado: (2022)

Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy
por: Amato, Rosario, et al.
Publicado: (2018)

β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo
por: Filippi, Luca, et al.
Publicado: (2021)

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model
por: Amato, Rosario, et al.
Publicado: (2021)

Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
por: Dal Monte, Massimo, et al.
Publicado: (2020)

A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma
por: Dal Monte, Massimo, et al.
Publicado: (2020)

Effects of Topical Gabapentin on Ocular Pain and Tear Secretion
por: Cammalleri, Maurizio, et al.
Publicado: (2021)

Increased efficacy of dietary supplement containing wax ester-rich marine oil and xanthophylls in a mouse model of dry macular degeneration
por: Melecchi, Alberto, et al.
Publicado: (2022)

Urokinase-type Plasminogen Activator Induces Neurorepair in the Ischemic Brain
por: Merino, Paola, et al.
Publicado: (2018)

In silico docking of urokinase plasminogen activator and integrins
por: Degryse, Bernard, et al.
Publicado: (2008)

Evaluation of Urokinase Plasminogen Activator Receptor, Soluble Urokinase Plasminogen Activator Receptor, and β1 Integrin in Patients with Hodgkin's Lymphoma
por: Kouhpayeh, Shirin, et al.
Publicado: (2017)

A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration
por: Rossino, Maria Grazia, et al.
Publicado: (2021)

Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor
por: Zhu, Ran, et al.
Publicado: (2022)

Localization of Urokinase‐type Plasminogen Activator, Plasminogen Activator Inhibitor‐1, 2 and Plasminogen in Colon Cancer
por: Naitoh, Hiroyuki, et al.
Publicado: (1995)

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors
Publicado: (1987)

Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse
Publicado: (1984)

Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
por: Lee, Ji-Hye, et al.
Publicado: (2014)

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type
Publicado: (1986)

A profile of transcriptomic changes in the rd10 mouse model of retinitis pigmentosa
por: Uren, Philip J., et al.
Publicado: (2014)

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator
por: Heynekamp, Justin J, et al.
Publicado: (2006)

Overexpression of urokinase-type plasminogen activator in pterygia and pterygium fibroblasts
por: Chao, Shih-Chun, et al.
Publicado: (2011)

Urokinase-type plasminogen activator receptor in IgA nephropathy
por: Ahn, Shin-Young, et al.
Publicado: (2014)

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
por: Ierodiakonou, Despo, et al.
Publicado: (2016)

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report
por: Sugioka, Koji, et al.
Publicado: (2012)

Electrophysiological and Histologic Evaluation of the Time Course of Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa
por: Jae, Seol A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_f7gfh8sjrmmhv1a66hnimk1s0o